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SCIENTIFIC LITERATURE · MED

Predictive modeling to uncover Parkinson's disease characteristics that delay diagnosis.

NPJ Parkinsons Dis · 2025-04-02

DOI: 10.1038/s41531-025-00923-2PMID: 40175384

Open accessbrief-report; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

PD patients present with diverse symptoms, complicating timely diagnosis. We analyzed 1124 PD trajectories using a novel model-based approach to estimate whether diagnosis was early or late compared to cohort averages. Higher age, specific non-motor symptoms, and fast disease progression were linked to later diagnosis, while gait impairment led to earlier diagnosis. Our findings are in line with a biological definition of PD that extends beyond classical motor symptoms.

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