Correlation Analysis Between 3D and Plane DAT Binding Parameters of <sup>11</sup>C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson's Disease.

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ObjectiveThe aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson's disease (PD) patients. Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD.MethodsA total of 75 patients with PD who underwent 11C-methyl-N-2β-methyl ester-3β-(4-fluorophenyl) tropane (11C-CFT) PET/CT from April, 2019 to June, 2021 were retrospectively analyzed. Clinical characteristics, including age, sex, and disease duration, as well as the modified Hoehn-Yahr (H-Y) scale, Unified Parkinson's Disease Rating Scale (UPDRS) parts II and III (II-III), and Mini-Mental State Examination (MMSE) scores of PD patients during the corresponding time periods were collected. DAT binding parameters and their derived parameters based on plane and 3D images in the neostriatum were analyzed for consistency with plane and 3D parameters, and the correlation between DAT parameters and the clinical features of patients were assessed using SPSS software.ResultsThe DAT binding parameters derived from 3D images demonstrated good consistency with the plane parameters (p p p p p p p ConclusionsQuantitative parameters based on plane and 3D images of 11C-CFT PET/CT showed good consistency. Moreover, 3D parameters in the neostriatum had a stronger correlation with activities of daily living, UPDRS motor scores, disease severity and duration, and cognition compared with plane parameters in PD patients.

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