NeuralCipher Research overview
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Background/Objectives: Mild cognitive impairment in Parkinson's disease (PD-MCI) affects approximately 20-50% of patients, and it is associated with an increased risk of dementia. Computer-assisted cognitive interventions (CCTs) have been proposed as a promising method of improving cognitive function in these patients. This review aims to (1) demonstrate the effectiveness of computer-based intervention in PD-MCI, and (2) determine the most effective iteration. Methods: A review was performed using PubMed, Google Scholar, and ScienceDirect. Full texts of randomized clinical trials (RCTs) involving CCT intervention in PD-MCI and published in English language journals between 2014 and 2024 were included. Results: Of the 747 studies identified, 6 studies fulfilled the eligibility criterion for this review. Patients receiving CCTs showed significant improvements in global cognition and executive function, while mood was not significantly affected in most studies. Conclusions: CCT improves cognitive functions, particularly memory and executive abilities, but has little effect on mood. Although the results are encouraging, there are potential methodological biases that need to be considered.
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