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SCIENTIFIC LITERATURE · MED

Long-term efficacy of deep brain stimulation in <i>PLA2G6</i>-related Parkinson's disease: A case report with literature review.

Clin Park Relat Disord · 2025-07-28

DOI: 10.1016/j.prdoa.2025.100377PMID: 40792120

Open accessJournal Article; Case Reports; case-reportOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

A patient with early-onset PARK14 and novel PLA2G6 variants underwent globus pallidus internus deep brain stimulation, achieving sustained three-year motor and quality-of-life improvements. Although a literature review supports motor benefits, our case's cognitive decline highlights the need for comprehensive assessment of non-motor symptoms and quality-of-life in this rare disorder.

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