NeuralCipher Research overview
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BackgroundExcessive exposure to manganese (Mn) causes parkinsonism. Occupational Mn exposure is associated with increased T1-weighted globus pallidus signal on magnetic resonance imaging (MRI) secondary to in-vivo Mn deposition.MethodsThe present study evaluated the T1-weighted pallidal index (PI) as an in-vivo marker of Mn exposure and neurotoxicity in chronic environmental Mn exposure. A total of 53 Black South African participants with a range of residential environmental Mn exposures due to proximity to one of the world's largest smelters underwent T1-weighted MRI.ResultsThe PI was associated with parkinsonism as measured by the total Unified Parkinson's Disease Rating Scale motor subsection part 3 (UPDRS3) in all participants (β=0.10, confidence interval 0.01, 0.18). Further, the PI was positively associated with total UPDRS3 scores (β=0.14, confidence interval 0.03, 0.25) and the lower limb rigidity subscore (β=0.04, confidence interval 0.005, 0.07) among those who regularly consumed alcohol (>3 drinks/week), but not in those who occasionally consumed alcohol (ConclusionOur findings suggest T1-weighted PI is associated with clinical neurotoxicity in environmental Mn exposure. This association is amplified by regular consumption of alcohol.
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