NeuralCipher Research overview
The text below is the source article’s original abstract under a verified reuse license. cc by
Gait assessments have been performed in several murine models of Parkinson's Disease (PD), but the M83+/- mouse model of PD has been relatively understudied in this context. Metrics of gait swing, stride length and frequency, and ataxia were collected in M83+/- mice with peripheral injections of α-syn preformed fibrils (PFF) and in aged M83+/- mice without fibrils using the DigiGait™ system. PFF-mice showed significantly decreased swing in all limbs (0.11 ± 0.02 vs. 0.13 ± 0.03, p = 0.007) compared to age-matched controls. Stride frequency was significantly increased in all limbs (3.9 ± 0.4 vs. 3.0 ± 0.5, p = 0.010) of PFF-treated mice. Swing was significantly greater in the hindlimbs of young M83+/-+PFF mice compared to aged M83+/- mice (0.11(0.5) vs. 0.08 (0.3), p = 0.015). Ataxia was significantly higher in young M83+/-+PFF mice compared to control for forelimbs (1.1 ± 1.0 vs. 0.6 ± 0.5, p = 0.027), hindlimbs (0.9 ± 1.0 vs. 0.3 ± 0.2, p = 0.016), and all limbs (1.0 ± 1.0 vs. 0.3 ± 0.5, p = 0.015). M83+/- mice demonstrate significant gait abnormalities consistent with features of PD. This study supports the utility of the M83+/- murine model for preclinical gait analyses in PD.
Scientific assessment
Research question
Assess the question within the original study’s scope.
Methods & sample
Check the source article for study design and sample details.
Key findings
An editorially approved findings summary is not yet published for this record.
Limitations
Generalizability, bias and clinical meaning require separate assessment.
Methods, samples and clinical conclusions are not inferred from bibliographic metadata.