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SCIENTIFIC LITERATURE · MED

A review of the evidence for a protective role of uric acid in Parkinson's disease.

NPJ Parkinsons Dis · 2025-11-19

DOI: 10.1038/s41531-025-01169-8PMID: 41257856

Open accessreview-article; Review; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

The relationship between the circulating antioxidant uric acid (UA) and Parkinson's disease (PD) has attracted much interest. This review of the evidence indicating whether UA may have a protective role in the development and/or progression of PD draws on the findings of reduced serum UA in PD, critically assesses the more equivocal genetic results, and discusses experimental observations that UA may provide protection against the pathogenic mechanisms of PD.

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