SCIENTIFIC LITERATURE · MED

Unraveling the intersection of aging and Parkinson's disease: a collaborative roadmap for advancing research models.

Schmidt MY, Cuervo AM, Double KL, Ehninger D, Goldberg MS, Harvey K, Hoeijmakers JHJ, Luk KC, Mastroberardino PG, Moore DJ, Niedernhofer LJ, Trudeau LÉ, Jurk D, Andersen JK, Bellantuono I.

NPJ Parkinsons Dis · 2026-01-16

DOI: 10.1038/s41531-025-01239-xPMID: 41545406

Open accessreview-article; Review; Journal ArticleOriginal source ↗

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The text below is the source article’s original abstract under a verified reuse license. cc by

Aging is the most significant risk factor for Parkinson's disease (PD), yet its role remains underexplored. The International Network for Parkinson's Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.

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