NeuralCipher Research overview
The text below is the source article’s original abstract under a verified reuse license. cc by
Transcranial ultrasound stimulation (TUS) is an emerging method for non-invasive neuromodulation of deep brain structures. However, to date, there is no evidence that TUS can directly modulate disease-related pathological oscillations in the same direction as known therapies. Inspired by clinical deep brain stimulation, in this randomised controlled cross-over study we probed the effects of pallidal TUS pulsed at 130 Hz on subthalamic beta-band activity, a biomarker in Parkinson's Disease (PD) in four male participants with PD. Beta-band power reduced in the ipsilateral subthalamic nucleus (STN) by 10.34% (95% CI:3.81% to 16.87%, p 2 = 0.980, p < 0.05, FDR adjusted), but not contralateral, STN and primary motor cortex. Bradykinesia, as measured by change in reaction time, was also reduced by 17.70% (95% CI:8.95% to 26.41%, p < 0.05, FDR adjusted). In this proof of concept study, we demonstrate that TUS can suppress pathological oscillations, potentially opening the door for therapeutic TUS (NCT06932185).
Scientific assessment
Research question
Assess the question within the original study’s scope.
Methods & sample
Check the source article for study design and sample details.
Key findings
An editorially approved findings summary is not yet published for this record.
Limitations
Generalizability, bias and clinical meaning require separate assessment.
Methods, samples and clinical conclusions are not inferred from bibliographic metadata.