Impacts of DNA ligase I genotypes on Taiwan Parkinson's disease.

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IntroductionGenetic polymorphisms in DNA repair pathways can modulate DNA repair capacity and influence susceptibility to aging-related disorders, including Parkinson's disease (PD). This study evaluated the association between the DNA ligase I rs20579 polymorphism and PD risk.Materials and methodsGenotyping of DNA ligase I rs20579 was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 123 PD patients and 492 age- and sex-matched controls of Taiwanese Han ethnicity. Associations between rs20579 genotypes and PD risk were analyzed.ResultsAmong controls, the genotype distribution of rs20579 was 78.7 % GG, 19.3 % AG, and 2.0 % AA, compared with 75.6 %, 21.1 %, and 3.3 % among PD cases, respectively (p for trend = 0.6290). No significant differences were observed in the prevalence of AG (p = 0.6939) or AA (p = 0.4908) genotypes between cases and controls. Allelic analysis showed a non-significant increase in PD risk for A allele carriers (OR = 1.21, 95 % CI = 0.80-1.83, p = 0.4189). Stratified analysis revealed no significant genotype differences among males. In females, the AA genotype was associated with a borderline increased risk of PD (OR = 1.86, 95 % CI = 1.00-3.47, p = 0.0526).ConclusionIn this Taiwanese Han cohort, the DNA ligase I rs20579 A allele may be a genetic marker of increased PD susceptibility in females. Further studies in larger, independent populations are warranted to confirm its clinical relevance.

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