SCIENTIFIC LITERATURE · PPR

GBA1 status and sex impact on depression severity and progression in Parkinson’s Disease

Mitrotti P, Avenali M, Artusi CA, De Micco R, Giannini G, Calabrese R, Gallo L, Galandra C, Ledda C, Mascia A, Siciliano M, Pagliuca F, Sambati L, Sant'Elia V, Vornetti G, Calandra-Buonaura G, Lopiano L, Lodi R, Tessitore A, Bozzali M, Valente EM.

· 2025-11-06

DOI: 10.21203/rs.3.rs-7929738/v1

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Abstract GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex impact occurrence and progression of depression. REM sleep behavior disorder predicted depression in GBA-PD, while sex, cognition, and motor complications were key predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.

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