NeuralCipher Research overview
The text below is the source article’s original abstract under a verified reuse license. cc by
Abstract Dysphagia is a substantial and often underrecognized burden in Parkinson’s disease (PD), and its neural underpinnings remain poorly understood. In this retrospective study, we employed a multimodal neuroimaging approach to investigate structural brain changes associated with dysphagia in PD. We included 105 participants in the age range of 45 to 84 years: 35 PD with dysphagia (PDD), 35 PD without dysphagia (PDnD), and 35 age- and sex-matched healthy controls (HC). Oropharyngeal dysphagia was confirmed through clinical swallowing evaluation or video fluoroscopic swallow study. We obtained T1 and diffusion-weighted MRI from all our participants. We analyzed them using voxel-based morphometry, surface-based morphometry, tract-based spatial statistics, and graph-theoretical structural connectivity analysis. Relative to HC and PDnD groups, the PDD group showed widespread gray matter atrophy ( p p p p
Scientific assessment
Research question
Assess the question within the original study’s scope.
Methods & sample
Check the source article for study design and sample details.
Key findings
An editorially approved findings summary is not yet published for this record.
Limitations
Generalizability, bias and clinical meaning require separate assessment.
Methods, samples and clinical conclusions are not inferred from bibliographic metadata.