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Abstract OBJECTIVE Immersive Virtual Reality Treatment for Parkinson's Disease (IVRTFPD study ) aims to compare the effect of immersive virtual reality training(VR) and audiovisual training (AV) for gait disorder in Parkinson's disease. METHODS Forty-four PD patients with gait disorder were enrolled and randomly divided into an immersive virtual reality (VR) group (n = 22), Audiovisual Treatment (AV) group (n = 22). The primary efficacy outcome measure was the change from baseline (Pre) to 6 weeks (Post 6w) and 14 weeks (Post 14w) visit in the Timed Up and Go test (TUGT). Magnetic resonance imaging (MRI) was assessed in baseline (Pre) and Post 14w visits. RESULTS The TUGT was reduced by 3.16s (95% CI, -4.18 to -2.13, P
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