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Abstract Background: To explore the correlation between dopamine transporter (DAT) PET/CT and the clinical characteristics and the scales of Parkinson’s disease (PD) patients, furthermore explore the scientificity and feasibility of incorporating 3D-dopaminergic binding parameters into the clinical scoring system for PD. Methods: A total of 75 patients with PD were retrospectively included. The clinical characteristics (including age, gender, disease duration), modified Hoehn-Yahr (H-Y) grading, UPDRS (the unified Parkinson's disease rating scale) II & III and Mini-Mental State Examination (MMSE) of PD patients in corresponding time periods were obtained. DAT binding parameters and their derived parameters based on plane and 3D images in neostriatum were analyzed for the consistency of plane and 3D parameters, and the correlation between the above parameters and the clinical characteristics of patients. Results: The DAT binding parameters based on 3D images had good consistency with the plane parameters (pppppppConclusions: The quantitative parameters based on plane and 3D images of 11C-CFT PET/CT had good consistency, and 3D parameters in neostriatum had a better correlation with the activities of daily living, UPDRS motor score, the severity and duration of disease and cognition than plane parameters in PD patients.
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