A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson’s disease and dementia with Lewy bodies

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INTRODUCTION Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns and common group-average analyses are limited in capturing individual differences. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. METHODS We generated z-scores from T1w-MRI scans for each participant (108 PD; 61 DLB) relative to normative regional cortical thickness and subcortical volumes, modelled in a reference cohort (n=58,836). Outliers (zRESULTS We found greater total outlier counts in PD poor visual performers, compared to high; and in DLB versus PD. Outlier counts were associated with global cognition in DLB, and visuoperception in PD. DISCUSSION Neuroanatomical normative modelling shows promise as a clinically informative technique in PD and DLB.

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