Investigating the relationship between cognitive disorders and fatigue in patients with Parkinson's and its relationship with individual and clinical factors in Isfahan city

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Abstract Parkinson's disease is a complex and debilitating disease caused by the degeneration of dopamine-producing brain cells due to the accumulation of α-synuclein, which affects the functioning of the front striatal networks. This research focused on collecting data meticulously by employing various methods. The data gathering process included interviews, examination of medical records, utilizing six checklists, and seeking expert opinions. Valuable insights were obtained from patients' files and input from respected healthcare professionals. Extensive neuropsychological questionnaires were used to thoroughly assess different cognitive areas. Furthermore, demographic details such as age, gender, marital status, education level, and employment status were diligently recorded. Clinical specifics like disease duration, stage, symptoms, medication usage, and sleep patterns were also analysed. The impact of fatigue in physical, cognitive, and psychosocial aspects was measured using the Parkinson's Fatigue Severity Scale (PFS). The Montreal Cognitive Assessment (MoCA) was utilized to evaluate general cognitive status, covering various cognitive domains. Mood symptoms were assessed through the 21-item Depression, Anxiety, and Stress Scale (DASS-21). Lastly, the Mini-Mental State Examination (MMSE) was employed to screen for global cognitive impairment. The research highlights the reliability and effectiveness of these assessment tools in evaluating cognitive functions, emotional states, and fatigue levels in individuals with Parkinson's disease.

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