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Safety, tolerability, and efficacy of flexible-dose tavapadon for Parkinson's disease (TEMPO-2): a phase 3, randomised, placebo-controlled, double-blind trial.

Fernandez HH, Bhatia P, Cloud L, Fietzek UM, Matarazzo M, Molho E, Peckham E, Tarakad A, Combs C, Leoni M, Chang I, Tringali S, Boiser J, Sanchez R, Zadikoff C.

Lancet Neurol · 2026-08-01

DOI: 10.1016/s1474-4422(26)00215-2PMID: 42456682

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.

Lange LM, Fang ZH, Makarious MB, Kuznetsov N, Atterling Brolin K, Ballard S, Bardien S, Doquenia ML, Heutink P, Houlden H, Iwaki H, Jasaityte S, Jones L, Junker J, Kaiyrzhanov R, Koretsky MJ, Kumar KR, Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), Leonard HL, Levine KS, Lim SY, Mencacci NE, Mohamed WMY, Nalls MA, Noyce AJ, Ojha R, Okubadejo NU, Ur Rehman S, Screven L, Shashkin C, Sopromadze S, Stafford EJ, Tan AH, Tan M, Tavadyan Z, Trinh J, Tserensodnom B, Valente EM, Vitale D, Zharkinbekova N, Lohmann K, Bandres-Ciga S, Blauwendraat C, Singleton AB, Morris HR, Klein C, Global Parkinson's Genetics Program (GP2).

Lancet Neurol · 2026-08-01

DOI: 10.1016/s1474-4422(26)00198-5PMID: 42456684

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
Open access

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

Richardson AE, Ferranti AS, Peng L, Lei X, Han A, Qi A, Rodriguez AL, Chang S, Sant S, Zagol-Ikapitte I, Krishnan S, Thompson Gray A, Wilkinson JC, Kethanapalli SH, Cho HP, Temple KJ, Mi D, Days EL, Bauer JA, Wijesiri NK, Brown BP, Boutaud O, Jones CK, Engers DW, Lindsley CW, Niswender CM, Crocker KE.

ACS Chem Neurosci · 2026-08-01

DOI: 10.1021/acschemneuro.6c00364PMID: 42460925

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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