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SCIENTIFIC LITERATURE · MED

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.

Sci Adv · 2025-12-17

DOI: 10.1126/sciadv.aed8002PMID: 41406219

Open accessResearch Support, Non-U.S. Gov't; review-article; Review; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

When two genes linked to increased Parkinson's risk converge on a lysosome, LRRK2 mutation enhances lysosomal release of soluble GPNMB potentially contributing to synuclein pathology.

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