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SCIENTIFIC LITERATURE · MED

CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson's disease.

Trends Neurosci · 2026-02-27

DOI: 10.1016/j.tins.2026.02.002PMID: 41763921

Open accessResearch Support, Non-U.S. Gov't; review-article; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Parkinson's disease comprises multiple biological subtypes and a heterogeneous clinical course. A recent study by Liao et al. identifies CHCHD2 mutations as a mitochondrial entry point that links metabolic dysfunction to α-synuclein pathology. These findings highlight how rare sporadiclike monogenic forms of Parkinson's disease may inform mechanistic and therapeutic stratification.

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