Effects of different exercises on motor and non-motor abilities in patients with Parkinson disease-a network meta-analysis of randomized controlled trials.

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ObjectiveTo systematically investigate and evaluate the effects of different exercise (TT: treadmill training; ST: sensorimotor training; NW: Nordic walking; CT: cycling training; WT: walking training; DT: dance training; VRT: VR training; RT: resistance training; AQT: aquatic training; BOX: boxing training; Qigong and Yoga) modalities on both motor and non-motor abilities in patients with Parkinson's disease.MethodsRandomized controlled trials (RCTs) concerning the impact of various exercise modes on motor and non-motor abilities in Parkinson's patients were identified by searching the PubMed, Web of Science, Cochrane library, CINAHL and CNKI databases. The search period spanned from the inception of each database to December 2025. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias tool.ResultsA total of 67 RCTs involving 2642 patients were included. Network meta-analysis results indicated that WT most effectively improved UPDRS-III (SUCRA=92.5%); DT was most effective in improving TUG (SUCRA=89.9%) and 6MWT (SUCRA=73.3%); NW best improved BBS (SUCRA=91.1%) and MoCA (SUCRA=91.1%). AQT best improved PDQ-39 (SUCRA=88.5%).ConclusionCurrent evidence suggests that exercise involving walking and dance, which stimulates neural regulation, can help improve motor function and cognitive abilities in people with Parkinson's disease. Patients can choose exercises based on their current fitness level.Systematic review registrationhttps://osf.io/7x5kc/.

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